Description
Product Characteristics:
The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activators (which increase the GTPase activity of G protein a-subunits) thereby driving G proteins into their inactive GDP-bound form. RGS21 (regulator of G-protein signaling 21) is a 152 amino acid protein that is ubiquitously expressed and contains one RGS domain. The gene encoding RGS21 maps to human chromosome 1q31.2 and mouse chromosome 1 F. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8 % of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson?s disease, Gaucher disease, schizophrenia and Usher syndrome.
Subcellular location: Cell membrane
Synonyms: Regulator of G-protein signaling 21, RGS21, RGS21_HUMAN.
Target Information: Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1, MIM 139310) and Gq (see GNAQ, MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination